ACNÉ SEVERO PUBLICACIONES CIENTÍFICAS

01

Jul 2015


MANAGEMENT OF SEVERE ACNE.

Zouboulis CC1, Bettoli V2. Br J Dermatol. 2015 Jul;172 Suppl 1:27-36. doi: 10.1111/bjd.13639.

ABSTRACT

Acne is the most common skin disease, affecting up to 95% of adolescents. Severe episodes of acne can cause considerable physical and psychological scarring, and overexpression of transforming growth factor-β can lead to formation of hypertrophic scars and keloids. The severity of acne in adolescence is associated with a positive history of severe acne in first-degree relatives, especially the mother. In most cases acne is a chronic disease, and it is often a component of systemic diseases or syndromes. All forms of severe acne require systemic treatment. The available options include oral antibiotics, hormonal antiandrogens for female patients and oral isotretinoin, as well as other combination treatments. Oral isotretinoin is the only drug available that affects all four pathogenic factors of acne. However, due to possible serious side-effects, a European directive states that oral isotretinoin should be used only as a second-line therapy in cases of severe, nodular and conglobate acne. The pharmaceutical quality of generic isotretinoin products and the obtainability of isotretinoin through e-pharmacies without prescription raise new therapeutic problems. New anti-inflammatory compounds, such as the 5-lipoxygenase inhibitor zileuton, may replace systemic antibiotics in the future, especially under the scope of antibiotic resistance prevention. This review looks into the various options and latest approaches, and factors to consider, when combating severe acne.

doctor

COMENTARIOS

Dra. Ariadna Ortiz Brugués, Ph. D., dermatóloga y directora médica Pierre Fabre Dermocosmética

En este artículo los autores hacen una revisión sobre el acné y su manejo. Destacan el papel de los antecedentes familiares, sobre todo maternos, en la severidad del acne en la adolescencia. No obstante, siempre deben descartarse otras enfermedades asociadas o síndromes en caso de sospecha.

Además, los autores inciden en que la isotretinoína oral es el único tratamiento sistémico que actúa sobre los cuatro factores implicados en la patogenia del acné.

“los autores inciden en que la isotretinoína oral es el único tratamiento sistémico que actúa sobre los cuatro factores implicados en la patogenia del acné.”

Juntos Contra el acné

Una iniciativa de Pierre Fabre Dermatologie una marca de Pierre Fabre Ibérica.